Natsume Inc. is a video game company that was once the American subidiary of the Japanese company Natsume Co., Ltd. They are most well known for publishing the Harvest Moon series and Rune Factory.

The company was established in 1988 and their first game was released in 1990. On June 4, 2013, they opened up a Tokyo office for in house development. It is being headed by Yasutaka Maekawa. The first title by this studio seems to be Harvest Moon 3D: The Lost Valley.